Medication RA

 

Drugs

 

This information is taken from Versus Arthritis

 

There are four main groups of drugs that are used to treat rheumatoid arthritis. These are:

 

  • painkillers – For information on pain relief medication go to: Pain Relief
  • non-steroidal anti-inflammatory drugs (NSAIDs)
  • disease-modifying anti-rheumatic drugs (DMARDs)
  • steroids (also known as corticosteroids).

 

Many people with rheumatoid arthritis need to take more than one drug. This is because different drugs work in different ways.

 

Your drug treatments may be changed from time to time. This can depend on how bad your symptoms are, or because something relating to your condition has changed.

 

Drugs may be available under several different names. Each drug has an approved name – sometimes called a generic name.

 

Manufacturers often give their own brand or trade name to the drug as well. For example, Nurofen is a brand name for ibuprofen.

 

The approved name should always be on the pharmacist’s label, even if a brand name appears on the packaging. Check with your doctor, rheumatology nurse specialist or pharmacist if you’re not sure about anything.

 

Disease-modifying anti-rheumatic drugs (DMARDs)

 

There are three types of DMARD:

 

  • conventional synthetic DMARDs (sometimes called csDMARDs)
  • biological therapies (sometimes called bDMARDs).
  • targeted synthetic DMARDs (sometimes called tsDMARDS).

 

You will need to have regular blood tests if you take DMARDs, as they can affect your liver.

 

It may be a while before you notice your DMARD working – possibly a few months. It is important to keep taking your medication during this time.

 

The table below shows the DMARDs available for the treatment of rheumatoid arthritis.

 

Name Type of DMARD
Azathioprine Conventional synthetic DMARD
Gold injections (Myocrisin) Conventional synthetic DMARD
Hydroxychloroquine (Plaquenil) Conventional synthetic DMARD
Leflunomide (Arava, Leflunomide medac, Leflunomide ratiopharm, Leflunomide Teva, Leflunomide Winthrop) Conventional synthetic DMARD
Methotrexate (Nordimet) Conventional synthetic DMARD
Sulfasalazine (Salazopyrin EN-Tabs) Conventional synthetic DMARD
Etanercept (Enbrel, Benepali, Erelzi) Biologic; Anti-TNF
Infliximab (Remicade, Remsima, Flixabi, Inflectra) Biologic; Anti-TNF
Rituximab (MabThera, Truxima, Rixathon) Biologic; Anti lymphocyte monoclonal antibody
Baricitinib (Olumiant) Targeted synthetic DMARD
Tofacitinib Targeted synthetic DMARD
Sarilumab Biologic: Anti IL6
Certolizumab pegol (Cimzia) Biologic; Anti-TNF
Adalimumab (Amgevita, Cyltezo, Humira, Imraldi) Biologic; Anti-TNF
Golimumab Biologic; Anti-TNF
Abatacept (Orencia) Biologic T cell co-stimulator
Tocilizumab Biologic; Anti IL6

 

 

 

Steroids

 

Steroids are sometimes known by their full name: corticosteroids.

 

Corticosteroids help to reduce the pain, stiffness and inflammation caused by rheumatoid arthritis.

 

They can be used as:

 

  • a tablet
  • an injection directly into a painful joint
  • an injection into your muscle.

 

They’re usually used to provide short-term pain relief. This could be during a flare-up or while you’re waiting for your DMARD medication to start working.

 

Corticosteroids are normally only used in this way because long-term use of corticosteroids can have serious side effects, including weight gain, osteoporosis and thinning of the skin.

 

You shouldn’t stop taking your steroid tablets or alter the dose unless advised to by your doctor. It can be dangerous to stop steroids suddenly.

 

Non-steroidal anti-inflammatory drugs (NSAIDs)

 

NSAIDs can be used to help control symptoms of pain, swelling or stiffness. They can be used in combination with painkillers.

 

NSAIDs start working within a few hours, with the effects felt for a few hours to a whole day.

 

Ibuprofen is a commonly prescribed NSAID.

 

NSAIDs can be taken as a:

 

  • tablet
  • capsule
  • liquid
  • suppository to be inserted into your bum
  • cream
  • gel.